Lionel Messi and new signing Luis Suarez are set to star as David Beckham-owned Inter Miami kick off Major League Soccer’s biggest season yet.

More eyes are on the United States and Canada’s top division than ever before as the league’s 29th season gets under way in Fort Lauderdale on Wednesday.

It is MLS’ earliest ever start to a campaign and begins with a standalone fixture as Miami play host to Real Salt Lake at newly renamed, and freshly upgraded, Chase Stadium.

Not only is the eight-time Ballon d’Or winner fit for Wednesday’s opener but Suarez is expected to make his competitive debut following his winter switch to Florida from Brazilian side Gremio.

Messi will be involved having overcome the inflamed adductor issue that saw him miss a high-profile pre-season friendly in Hong Kong, sparking fury from expectant ticket-holders.

“They’re playing and they’re ready to play,” Inter Miami coach Tata Martino said of Messi and the former Liverpool striker.

“If they’re required to play 90 minutes, we’re going to look at it always depending on the need of the team.”

Suarez is the latest former Barcelona star to rock up in Miami, where he has joined Messi, Sergio Busquets and Jordi Alba.

“It’s good, very positive,” left-back Alba said on the eve of the MLS opener. “When we got here we found a coach, players and staff who are spectacular. Like a family. They treat us very well.

“For Luis, besides the fact we’re friends, he is going to bring us a lot in attack and is a great player.

“(The younger players) always listen when we talk and we are here to give them advice. We all get along well.

“In all teams you have veterans and young players, building a positive environment for the benefit of the team.”

Messi, Busquets and Alba have already won their first trophy in Miami’s eye-catching pink kit, having roared to victory in the inaugural Leagues Cup last year.

The competition provided a memorable start to their life in North America and Alba is eyeing more silverware this term.

“We have a lot of big players but that doesn’t mean anything, you have to show what you can do,” the former Spain international said. “It is going to be hard.

“Hopefully we can win all the titles. I understand the fans’ enthusiasm and the expectations they have for the team, but we have to show it on the field and we think we’re on a good path.”