Cheltenham Festival runner-up Kargese follows a familiar route for Willie Mullins in the Boodles Anniversary 4-Y-O Juvenile Hurdle at Aintree on Thursday.

The Closutton handler has claimed this Grade One contest twice in the last seven years, with both the sensational 2016 victor Apple’s Jade and last year’s heroine Zenta picking up minor honours in the Triumph Hurdle prior to striking gold on Merseyside.

His latest challenger is a pea out of the same pod having found only stablemate Majborough too strong at Prestbury Park last month – and while Nicky Henderson’s unbeaten Triumph absentee Sir Gino is a major threat, connections of Kargese are quietly confident about her chances.

“If she’s come out of Cheltenham well, which the team at Closutton seem to think she has, she must have every chance,” said Peter Molony, racing manger for owner Kenny Alexander.

“She just needs to learn to settle a little bit. I would upgrade her run big time in the Triumph as she basically fought for her head the whole way round and never really settled. Before the last she looked like she was galloping all over the winner and then she just got tired.

“I know the winner is very good, but I think she definitely would have got closer to him if she had settled better, so if she can settle on Thursday we’d be very hopeful.

“She’s a very nice mare who owes us nothing as she’s had a great year already, but we rate her pretty highly so hopefully she can settle and we’ll have a good run.”

Sir Gino looked every inch a top-class prospect after winning his first two starts for Nicky Henderson, particularly when dominating his rivals in a Triumph Hurdle trial at Cheltenham in late January.

The French import disappointingly missed the Triumph Hurdle itself during what was a difficult week for his trainer, but that does at least mean he will be fresh for his latest assignment.

“It was sad he couldn’t run at Cheltenham because, to be fair, there was nothing wrong with him but by the time we got to the Friday I’d completely lost my bottle altogether,” Henderson told Unibet.

“I didn’t dare run him. I think he’s a very good horse and we’re going to find out sooner or later. He looked very good on Trials day at Cheltenham and his work recently has been up to that standard.

“He’s been round Auteuil so the ground shouldn’t worry him.”

Similar comments apply to the Paul Nicholls-trained Kalif Du Berlais, who is two from two since arriving in Britain and has been saved for Aintree since landing the Adonis at Kempton in February.

“He’s a horse with a big future and maintained his unbeaten record with a determined success in the Adonis Hurdle at Kempton under a 5lb penalty,” Nicholls told Betfair.

“It was always the plan to miss the Triumph Hurdle and wait for this race at Aintree. We’ve deliberately given him time and although this is a step up in class for him, he seems be improving physically and I think he is in better shape than he was before his last run.”

Joseph O’Brien saddles both Triumph Hurdle fourth Nurburgring and his stablemate Intellotto, who was last seen landing a small-field conditions event at Limerick.

Syd Hosie’s rank outsider and hurdling debutant Dirty Den, down the field in the Champion Bumper last month, completes the field.