England have suffered a setback on the eve of their Autumn Nations Cup final against France after Mako Vunipola was ruled out by an Achilles problem.

Vunipola sustained the injury against Wales last Saturday and has been unable to recover in time for Sunday’s Twickenham showdown.

Ellis Genge is promoted from the bench into the starting XV, with Joe Marler filling the vacancy among the replacements.

Attack coach Simon Amor said: “Mako picked up an injury in last week’s game. We’ve given him every opportunity to recover for this one but unfortunately he hasn’t made it.”

Vunipola had re-established himself as England’s first choice loosehead prop after Marler missed the start of the autumn because of a knee injury, with Genge now second in the revised pecking order for a position where England have genuine depth.

“It’s disappointing to lose any player.

“In Ellis Genge and Joe Marler we’ve got two outstanding looseheads there. They’ve trained well this week,” Amor said.

“Ellis is a real bowling ball in terms of his carries, so he’ll bring that aggression with the ball.

“He’s a very destructive scrummager and he brings a real energy to the team. He’s a great one to bring in.”