Manchester United have defensive issues ahead of their Premier League derby clash with Manchester City at Old Trafford.

Raphael Varane faces four to five weeks on the sidelines with a hamstring injury suffered during the Champions League game against Atalanta, while Victor Lindelof faces a fitness test on the knock that forced him to miss Tuesday’s 2-2 draw.

Paul Pogba serves the second game of a three-match domestic ban but Fred should return in midfield after being benched in Italy.

City centre-back Aymeric Laporte is suspended after being sent off in last week’s loss to Crystal Palace.

Manager Pep Guardiola will also check on Kyle Walker after the England full-back suffered a foot injury against Club Brugge on Wednesday.

Winger Ferran Torres (foot) is City’s only other notable absentee.

Manchester United provisional squad: De Gea, Henderson, Lindelof, Bailly, Maguire, Dalot, Shaw, Telles, Wan-Bissaka, Mata, Lingard, Fred, Fernandes, Matic, Van De Beek, McTominay, Ronaldo, Martial, Rashford, Greenwood, Cavani, Sancho.

Manchester City provisional squad: Ederson, Steffen, Carson, Walker, Cancelo, Dias, Stones, Ake, Zinchenko, Fernandinho, Gundogan, Silva, De Bruyne, Foden, Mahrez, Palmer, Grealish, Rodri, Sterling, Jesus.